PRP vs Rejuran: Skin Rejuvenation Comparison

October 25, 2026

PRP and Rejuran are both injectable treatments aimed at the same broad goal: healthier, more resilient skin with better texture and elasticity. For a visitor to Busan, the big practical difference is where the active ingredient comes from. PRP is made from your own blood on the day; Rejuran is a manufactured PN booster. That affects who can have each, what the appointment involves and how much evidence sits behind it.

Quick answer: PRP (platelet-rich plasma) concentrates platelets from a small sample of your own blood and injects them into the skin, where their growth factors support renewal and collagen. It suits sensitive skin and people who prefer an autologous option, but needs a blood draw and results vary between individuals. Rejuran Healer uses salmon-derived PN to support skin repair and is a standardised product with a long track record in Korea, but is unsuitable with fish allergy. Both need a series of about 3 sessions. Rejuran is often the more predictable choice; PRP is a good alternative if you react to many products.

How PRP works

A small amount of blood is drawn and spun in a centrifuge to separate the platelet-rich plasma. Platelets contain growth factors involved in tissue repair. Injected into the skin, they signal cells to renew and can support collagen production. Because the material comes from your own body, an allergic reaction to it is unlikely.

How Rejuran works

Rejuran Healer, by PharmaResearch in Korea, contains PN (polynucleotide) purified from salmon DNA. PN supports fibroblast activity and the skin's natural repair, gradually improving structure and resilience. It is injected in small, even points after numbing cream.

What the evidence says

  • PRP: widely used in medicine and aesthetics, with studies showing benefits for skin quality in some people. However, preparation methods and platelet concentration differ between systems and between patients, so results are less predictable and the evidence is mixed in quality.
  • Rejuran: a standardised product with supportive clinical data and many years of use in Korea. Improvements are gradual and moderate; dramatic "regeneration" claims go beyond the evidence.

Neither treatment replaces lifting for sagging or filler for volume loss.

Key differences

  • Source: your own blood (PRP) vs salmon-derived PN (Rejuran).
  • Consistency: PRP varies from person to person; Rejuran is a standardised product.
  • Appointment: PRP includes a blood draw and preparation, about 20–30 minutes in total; Rejuran takes about 10–20 minutes after numbing.
  • Allergy: PRP has very low allergy risk to the material; Rejuran is unsuitable with fish or salmon allergy.
  • Session spacing: PRP about every 3–4 weeks; Rejuran every 2–4 weeks.

Who suits which

PRP may suit you if

  • Your skin reacts easily to many products and you prefer an autologous option.
  • You want gradual improvement in tone, texture and elasticity.
  • You are comfortable with a routine blood draw.

Rejuran may suit you if

  • Your skin feels thin, fragile or slow to recover after sun, stress or lasers.
  • You want a standardised product with a longer track record.
  • You do not want a blood draw.

Who should avoid or wait

PRP is not suitable with a blood or platelet disorder or low platelet count, blood thinners, active cancer or cancer treatment, fever or illness, pregnancy or breastfeeding, or active skin infection. If you faint easily with needles or cannot have blood drawn, a booster such as a stem cell skin booster or Rejuran needs no blood draw. Rejuran is avoided with fish allergy, pregnancy or breastfeeding, active infection, an uncontrolled autoimmune condition or keloid tendency.

Cost in Busan

Example prices at a clinic in Seomyeon:

  • Autologous PRP 3cc + full-face skin Botox + hydration injection 2cc + soothing mask : from KRW 390,000
  • Rejuvelook (Rejuran 2cc + Juvelook Skin 2cc) : from KRW 319,000
  • Rejuran HB 2cc : from KRW 390,000
  • Rejuran 2cc + Juvelook Skin 2cc + hydration injection 2cc + full-face skin Botox : from KRW 590,000

Prices checked October 2026. They exclude 10% VAT, which is added at payment, and prices change frequently. Both are typically offered in packages with other treatments, so compare what is bundled. Budget for around three sessions.

What happens on the day

PRP

  1. The doctor reviews your health, medications and skin.
  2. A small blood sample is drawn and spun to separate the plasma, while numbing cream is applied.
  3. The plasma is injected into the skin.
  4. Eat and drink water before your visit, especially if travelling afterwards.

Rejuran

  1. The doctor checks your skin and asks about fish allergy.
  2. Numbing cream for about 20–30 minutes.
  3. Injections for about 10–20 minutes; PN boosters can sting slightly, and small blebs form.

Downtime and aftercare

  • PRP: mild redness, small bumps and needle marks for 1–3 days; possible bruising at the blood-draw site.
  • Rejuran: raised bumps for a few hours, needle marks and mild swelling for 1–2 days, especially under the eyes.

For both, avoid lying down or rubbing your face for 3–4 hours, skip alcohol, saunas, hot baths and strenuous exercise on the day, and leave makeup until the next day. Light sightseeing is usually fine the same afternoon; save the jjimjilbang for later in your trip. Rarely, infection can occur after either; contact the clinic if redness or pain worsens.

Results timeline

  • Weeks 2–4: skin begins to look healthier and more even.
  • After about 3 sessions: clearer change in texture, tone and elasticity.
  • Ongoing: maintenance every few months, depending on your skin.

Frequently asked questions

Is PRP safer because it is my own blood?

Allergy to the material itself is unlikely, but PRP still involves injections and a blood draw, with risks such as bruising and, rarely, infection. It is not suitable for everyone, particularly people with blood disorders or on blood thinners.

Which gives faster results?

Both work gradually over a series. Neither is designed for an instant change before an event.

Can I combine PRP and Rejuran?

They can be part of the same overall plan, usually in separate sessions. A doctor will advise on spacing based on your skin and travel dates.

Comparing PRP and Rejuran?
Send a daylight photo, any allergies or medications, and your travel dates on WhatsApp to get a plan and today's price in English.

This article is for general information and does not replace a medical consultation. Suitability, results, recovery and side effects vary from person to person.

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